{"id":1,"date":"2024-01-11T06:07:54","date_gmt":"2024-01-11T06:07:54","guid":{"rendered":"https:\/\/clinic2.hiro-test.net\/gene\/?p=1"},"modified":"2024-12-10T07:40:54","modified_gmt":"2024-12-10T07:40:54","slug":"hello-world","status":"publish","type":"post","link":"https:\/\/clinic2.hiro-test.net\/gene\/hello-world\/","title":{"rendered":"\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u5065\u5eb7\u9577\u5bff\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u306f\u3058\u3081\u306b<\/strong><\/h3>\n\n\n\n<p>\u73fe\u4ee3\u306e\u533b\u7642\u3068\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u9032\u5316\u306b\u3088\u308a\u3001\u79c1\u305f\u3061\u306f\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3066\u81ea\u5206\u81ea\u8eab\u306e\u4f53\u8cea\u3084\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u628a\u63e1\u3057\u3001\u5065\u5eb7\u9577\u5bff\u3092\u76ee\u6307\u3059\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u306f\u3001\u79c1\u305f\u3061\u306e\u4f53\u8cea\u3084\u751f\u6d3b\u7fd2\u6163\u75c5\u30ea\u30b9\u30af\u3001\u3055\u3089\u306b\u306f\u8001\u5316\u306e\u901f\u5ea6\u306b\u307e\u3067\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u304a\u308a\u3001\u3053\u308c\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5065\u5eb7\u5bff\u547d\u306e\u5ef6\u9577\u3068QOL\uff08Quality of Life\uff09\u306e\u5411\u4e0a\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u5065\u5eb7\u9577\u5bff\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u3001\u8001\u5316\u4e88\u9632\u3084\u75c5\u6c17\u30ea\u30b9\u30af\u7ba1\u7406\u306e\u305f\u3081\u306e\u5177\u4f53\u7684\u306a\u65b9\u6cd5\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u5065\u5eb7\u9577\u5bff\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306f\u3001\u79c1\u305f\u3061\u306e\u5065\u5eb7\u3084\u5bff\u547d\u306b\u76f4\u63a5\u7684\u306b\u95a2\u308f\u3063\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u30bf\u30a4\u30d7\u3084\u5909\u7570\u304c\u3001\u8001\u5316\u901f\u5ea6\u3084\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u9577\u5bff\u3068\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u4ee3\u8868\u7684\u306a\u3082\u306e\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u4e88\u9632\u7b56\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u304c\u5065\u5eb7\u9577\u5bff\u306e\u9375\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u5065\u5eb7\u9577\u5bff\u306b\u95a2\u308f\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FOXO3\u907a\u4f1d\u5b50<\/strong>\uff1a\u9577\u5bff\u907a\u4f1d\u5b50\u3068\u3057\u3066\u5e83\u304f\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u7d30\u80de\u306e\u8001\u5316\u6291\u5236\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306e\u5411\u4e0a\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\u3001\u5065\u5eb7\u5bff\u547d\u306e\u5ef6\u9577\u306b\u5f79\u7acb\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>SIRT1\u907a\u4f1d\u5b50<\/strong>\uff1a\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u3068\u547c\u3070\u308c\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3084\u708e\u75c7\u6291\u5236\u3001\u7d30\u80de\u4fee\u5fa9\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3001\u6297\u8001\u5316\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>APOE\u907a\u4f1d\u5b50<\/strong>\uff1a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3067\u3001APOE\u306e\u7279\u5b9a\u306e\u30bf\u30a4\u30d7\u304c\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u3067\u3001\u79c1\u305f\u3061\u306f\u81ea\u5206\u81ea\u8eab\u306b\u6700\u9069\u306a\u5065\u5eb7\u7ba1\u7406\u65b9\u6cd5\u3084\u8001\u5316\u4e88\u9632\u306e\u305f\u3081\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3092\u9078\u629e\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u5065\u5eb7\u9577\u5bff\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u6297\u9178\u5316\u5bfe\u7b56\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u7ba1\u7406\uff08FOXO3\u907a\u4f1d\u5b50\uff09<\/strong><\/h4>\n\n\n\n<p>FOXO3\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u304c\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u306b\u8010\u3048\u3001\u5065\u5eb7\u3092\u4fdd\u3064\u3046\u3048\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u5834\u5408\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u5f37\u304f\u306a\u308a\u3001\u7d30\u80de\u306e\u8001\u5316\u901f\u5ea6\u304c\u9045\u304f\u306a\u308a\u307e\u3059\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u306f\u3001\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u304c\u904e\u5270\u306b\u751f\u6210\u3055\u308c\u308b\u72b6\u614b\u3067\u3001\u3053\u308c\u304c\u5897\u3048\u308b\u3068\u7d30\u80de\u304c\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u3001\u8001\u5316\u3084\u75c5\u6c17\u306e\u9032\u884c\u304c\u65e9\u307e\u308b\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3C\u3084\u30d3\u30bf\u30df\u30f3E\u306e\u6442\u53d6<\/strong>\uff1a\u3053\u308c\u3089\u306e\u6297\u9178\u5316\u30d3\u30bf\u30df\u30f3\u306f\u3001\u4f53\u5185\u306e\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3059\u3002\u67d1\u6a58\u985e\u3001\u30ca\u30c3\u30c4\u3001\u7a2e\u5b50\u985e\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3068\u826f\u3044\u3067\u3057\u3087\u3046\u3002<\/li>\n\n\n\n<li><strong>\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u3068\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb<\/strong>\uff1a\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\uff08\u30c8\u30de\u30c8\u3084\u30cb\u30f3\u30b8\u30f3\u306a\u3069\u306e\u8272\u7d20\u6210\u5206\uff09\u3084\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08\u30d6\u30c9\u30a6\u3084\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\u306b\u591a\u304f\u542b\u307e\u308c\u308b\uff09\u306f\u3001\u5f37\u529b\u306a\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3061\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8efd\u6e1b\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong>\uff1a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16862167\/\">FOXO3\u907a\u4f1d\u5b50\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u95a2\u3059\u308b\u7814\u7a76<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. 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class=\"wp-block-list\">\n<li><strong>\u30ab\u30ed\u30ea\u30fc\u5236\u9650<\/strong>\uff1aSIRT1\u907a\u4f1d\u5b50\u306f\u3001\u98df\u4e8b\u306e\u30ab\u30ed\u30ea\u30fc\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u6d3b\u6027\u5316\u3055\u308c\u3001\u7d30\u80de\u306e\u4fee\u5fa9\u80fd\u529b\u304c\u5411\u4e0a\u3057\u307e\u3059\u3002\u904e\u5ea6\u306a\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306f\u907f\u3051\u3064\u3064\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u3092\u5fc3\u304c\u3051\u308b\u3053\u3068\u3067\u3001\u4ee3\u8b1d\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb<\/strong>\uff1a\u8d64\u30ef\u30a4\u30f3\u3084\u30d6\u30c9\u30a6\u306b\u542b\u307e\u308c\u308b\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306f\u3001SIRT1\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304a\u308a\u3001\u4ee3\u8b1d\u306e\u6539\u5584\u3084\u708e\u75c7\u6291\u5236\u306b\u5f79\u7acb\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong>\uff1a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18191527\/\">SIRT1\u907a\u4f1d\u5b50\u3068\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306b\u3088\u308b\u6297\u8001\u5316\u306b\u95a2\u3059\u308b\u7814\u7a76<\/a><\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><p><strong>test<\/strong><\/p>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. 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class=\"wp-block-list\">\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178<\/strong>\uff1a\u9b5a\u306b\u591a\u304f\u542b\u307e\u308c\u308b\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08DHA\u30fbEPA\uff09\u306f\u3001\u8133\u306e\u5065\u5eb7\u7dad\u6301\u3084\u708e\u75c7\u6291\u5236\u306b\u6709\u52b9\u3067\u3059\u3002\u9b5a\u3092\u5b9a\u671f\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001APOE\u907a\u4f1d\u5b50\u304c\u6301\u3064\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30d6\u30c9\u30a6\u30fb\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc<\/strong>\uff1a\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3092\u591a\u304f\u542b\u3080\u98df\u6750\u306f\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u6539\u5584\u3084\u8133\u7d30\u80de\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8efd\u6e1b\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong>\uff1a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10679800\/\">APOE\u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u7814\u7a76<\/a><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u65e5\u5e38\u751f\u6d3b\u3067\u53d6\u308a\u5165\u308c\u308b\u3079\u304d\u7fd2\u6163\u3068\u5177\u4f53\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3066\u3001\u5065\u5eb7\u9577\u5bff\u3092\u76ee\u6307\u3059\u305f\u3081\u306e\u5177\u4f53\u7684\u306a\u751f\u6d3b\u7fd2\u6163\u3092\u4ee5\u4e0b\u306b\u307e\u3068\u3081\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u6804\u990a\u30d0\u30e9\u30f3\u30b9\u306e\u898b\u76f4\u3057<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u3001\u4e0d\u8db3\u3057\u304c\u3061\u306a\u6804\u990a\u7d20\u3092\u88dc\u3046\u3053\u3068\u306f\u3001\u5065\u5eb7\u9577\u5bff\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\u3092\u4e2d\u5fc3\u306b\u3001\u5fc5\u8981\u306a\u6804\u990a\u3092\u3057\u3063\u304b\u308a\u3068\u6442\u53d6\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3\u3068\u30df\u30cd\u30e9\u30eb<\/strong>\uff1a\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u3092\u9632\u3050\u30d3\u30bf\u30df\u30f3A\u3001C\u3001E\u3001\u30bb\u30ec\u30f3\u3001\u4e9c\u925b\u3092\u542b\u3080\u98df\u54c1\u3092\u6442\u53d6\u3057\u307e\u3059\u3002\u67d1\u6a58\u985e\u3001\u7dd1\u9ec4\u8272\u91ce\u83dc\u3001\u30ca\u30c3\u30c4\u985e\u3001\u7a40\u7269\u3092\u7a4d\u6975\u7684\u306b\u53d6\u308a\u5165\u308c\u307e\u3057\u3087\u3046\u3002<\/li>\n\n\n\n<li><strong>\u30d7\u30ed\u30c6\u30a4\u30f3<\/strong>\uff1a\u826f\u8cea\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7b4b\u8089\u306e\u7dad\u6301\u3068\u4fee\u5fa9\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u5375\u3001\u8c46\u985e\u3001\u9b5a\u306a\u3069\u306e\u826f\u8cea\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u6e90\u3092\u98df\u4e8b\u306b\u542b\u3081\u3001\u7b4b\u8089\u306e\u8870\u3048\u3092\u9632\u304e\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u9069\u5ea6\u306a\u904b\u52d5\u7fd2\u6163<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u9069\u5207\u306a\u904b\u52d5\u30d7\u30e9\u30f3\u306f\u3001\u7b4b\u8089\u91cf\u3092\u7dad\u6301\u3057\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u305f\u3081\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u904b\u52d5\u306e\u7a2e\u985e\u3084\u5f37\u5ea6\u3082\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6709\u9178\u7d20\u904b\u52d5<\/strong>\uff1a\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3001\u30b8\u30e7\u30ae\u30f3\u30b0\u3001\u6c34\u6cf3\u306a\u3069\u306e\u6709\u9178\u7d20\u904b\u52d5\u306f\u3001\u5fc3\u80ba\u6a5f\u80fd\u3092\u7dad\u6301\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3059\u308b\u306e\u306b\u52b9\u679c\u7684\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a\u5e74\u9f62\u306b\u5fdc\u3058\u305f\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\u3001\u7b4b\u8089\u91cf\u3092\u7dad\u6301\u3057\u3001\u57fa\u790e\u4ee3\u8b1d\u3092\u4fdd\u3064\u305f\u3081\u306b\u91cd\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. 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class=\"wp-block-list\">\n<li><strong>\u898f\u5247\u7684\u306a\u7761\u7720\u30d1\u30bf\u30fc\u30f3<\/strong>\uff1a\u6bce\u65e5\u540c\u3058\u6642\u9593\u306b\u5bdd\u8d77\u304d\u3059\u308b\u3053\u3068\u3067\u3001\u4f53\u5185\u30ea\u30ba\u30e0\u304c\u6574\u3044\u3001\u6df1\u3044\u7720\u308a\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u7761\u7720\u74b0\u5883\u306e\u6574\u5099<\/strong>\uff1a\u5feb\u9069\u306a\u5bdd\u5177\u3001\u6697\u3044\u90e8\u5c4b\u3001\u9069\u5207\u306a\u5ba4\u6e29\u3092\u4fdd\u3064\u3053\u3068\u3067\u3001\u30ea\u30e9\u30c3\u30af\u30b9\u3057\u3066\u7720\u308a\u3084\u3059\u3044\u74b0\u5883\u3092\u6574\u3048\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>4. 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class=\"wp-block-list\">\n<li><strong>\u7791\u60f3\u3084\u30e8\u30ac<\/strong>\uff1a\u547c\u5438\u3092\u6574\u3048\u3001\u5fc3\u3092\u843d\u3061\u7740\u304b\u305b\u308b\u3053\u3068\u3067\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u3092\u6291\u3048\u3001\u30ea\u30e9\u30c3\u30af\u30b9\u3057\u305f\u6c17\u5206\u3092\u4fdd\u3064\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8da3\u5473\u3092\u697d\u3057\u3080<\/strong>\uff1a\u81ea\u5206\u306e\u597d\u304d\u306a\u8da3\u5473\u306b\u6ca1\u982d\u3059\u308b\u6642\u9593\u3092\u6301\u3064\u3053\u3068\u3082\u3001\u30b9\u30c8\u30ec\u30b9\u89e3\u6d88\u3068\u5e78\u798f\u611f\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u52b9\u679c\u7684\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u6d3b\u7528\u306e\u30e1\u30ea\u30c3\u30c8\u3068\u8ab2\u984c<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30e1\u30ea\u30c3\u30c8<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u500b\u5225\u5bfe\u5fdc\u306e\u5065\u5eb7\u7ba1\u7406<\/strong>\uff1a\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u3001\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u306a\u5065\u5eb7\u7ba1\u7406\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u6700\u9069\u5316\u304c\u53ef\u80fd\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u65e9\u671f\u4e88\u9632\u306e\u53ef\u80fd\u6027<\/strong>\uff1a\u907a\u4f1d\u7684\u306a\u30ea\u30b9\u30af\u8981\u56e0\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u6d3b\u7fd2\u6163\u3092\u898b\u76f4\u3057\u3001\u5065\u5eb7\u9577\u5bff\u3078\u306e\u4e88\u9632\u7b56\u304c\u8b1b\u3058\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u6539\u5584<\/strong>\uff1a\u904b\u52d5\u3084\u6804\u990a\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u5177\u4f53\u7684\u306b\u6d3b\u304b\u3059\u3053\u3068\u3067\u3001\u65e5\u5e38\u751f\u6d3b\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u8ab2\u984c<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u984d\u306a\u30b3\u30b9\u30c8<\/strong>\uff1a\u9ad8\u7cbe\u5ea6\u306a\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u306f\u9ad8\u984d\u306a\u8cbb\u7528\u304c\u304b\u304b\u308b\u305f\u3081\u3001\u5229\u7528\u306e\u30cf\u30fc\u30c9\u30eb\u304c\u9ad8\u3044\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30c7\u30fc\u30bf\u306e\u4fdd\u8b77\u3068\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc<\/strong>\uff1a\u907a\u4f1d\u60c5\u5831\u306f\u500b\u4eba\u60c5\u5831\u306e\u4e2d\u3067\u3082\u7279\u306b\u30bb\u30f3\u30b7\u30c6\u30a3\u30d6\u3067\u3042\u308b\u305f\u3081\u3001\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u306e\u4fdd\u8b77\u304c\u91cd\u8981\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5c02\u9580\u7684\u306a\u30b5\u30dd\u30fc\u30c8\u306e\u5fc5\u8981\u6027<\/strong>\uff1a\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6b63\u3057\u304f\u7406\u89e3\u3057\u6d3b\u7528\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u533b\u5e2b\u3084\u5c02\u9580\u5bb6\u306e\u30b5\u30dd\u30fc\u30c8\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u5065\u5eb7\u9577\u5bff\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u8001\u5316\u4e88\u9632\u3084\u75c5\u6c17\u30ea\u30b9\u30af\u7ba1\u7406\u306e\u305f\u3081\u306e\u975e\u5e38\u306b\u6709\u52b9\u306a\u624b\u6bb5\u3067\u3059\u3002FOXO3\u3084SIRT1\u3001APOE\u306a\u3069\u306e\u907a\u4f1d\u5b50\u3092\u901a\u3058\u3066\u3001\u81ea\u5206\u306e\u4f53\u8cea\u3084\u30ea\u30b9\u30af\u8981\u56e0\u3092\u77e5\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u5065\u5eb7\u7ba1\u7406\u304c\u5b9f\u73fe\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u500b\u5225\u5bfe\u5fdc\u306e\u5065\u5eb7\u7fd2\u6163\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u5065\u5eb7\u5bff\u547d\u306e\u5ef6\u4f38\u3068\u751f\u6d3b\u306e\u8cea\u306e\u5411\u4e0a\u3092\u76ee\u6307\u3057\u3001\u81ea\u5206\u306b\u6700\u9069\u306a\u5065\u5eb7\u7dad\u6301\u6cd5\u3092\u898b\u3064\u3051\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3001\u65e5\u3005\u306e\u751f\u6d3b\u306e\u8cea\u3092\u9ad8\u3081\u3001\u5065\u5eb7\u9577\u5bff\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u306e\u4e00\u6b69\u3092\u8e0f\u307f\u51fa\u3057\u3066\u307f\u3066\u306f\u3044\u304b\u304c\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>\u53c2\u8003\u6587\u732e\u30fb\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16862167\/\">FOXO3\u907a\u4f1d\u5b50\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u95a2\u3059\u308b\u7814\u7a76<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18191527\/\">SIRT1\u907a\u4f1d\u5b50\u3068\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306b\u3088\u308b\u6297\u8001\u5316\u306b\u95a2\u3059\u308b\u7814\u7a76<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10679800\/\">APOE\u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u7814\u7a76<\/a><\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><p><strong>test<\/strong><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u306f\u3058\u3081\u306b \u73fe\u4ee3\u306e\u533b\u7642\u3068\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u9032\u5316\u306b\u3088\u308a\u3001\u79c1\u305f\u3061\u306f\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3066\u81ea\u5206\u81ea\u8eab\u306e\u4f53\u8cea\u3084\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u628a\u63e1\u3057\u3001\u5065\u5eb7\u9577\u5bff\u3092\u76ee\u6307\u3059\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u306f\u3001\u79c1\u305f\u3061\u306e\u4f53\u8cea\u3084\u751f\u6d3b\u7fd2\u6163\u75c5\u30ea\u30b9\u30af\u3001\u3055\u3089\u306b\u306f\u8001\u5316\u306e\u901f\u5ea6\u306b\u307e\u3067\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u304a\u308a\u3001\u3053\u308c\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5065\u5eb7\u5bff\u547d\u306e\u5ef6\u9577\u3068QOL\uff08Quality of Life\uff09\u306e\u5411\u4e0a\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002 \u672c\u8a18\u4e8b\u3067\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u5065\u5eb7\u9577\u5bff\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u3001\u8001\u5316\u4e88\u9632\u3084\u75c5\u6c17\u30ea\u30b9\u30af\u7ba1\u7406\u306e\u305f\u3081\u306e\u5177\u4f53\u7684\u306a\u65b9\u6cd5\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002 \u907a\u4f1d\u5b50\u3068\u5065\u5eb7\u9577\u5bff\u306e\u95a2\u4fc2 \u907a\u4f1d\u5b50\u306f\u3001\u79c1\u305f\u3061\u306e\u5065\u5eb7\u3084\u5bff\u547d\u306b\u76f4\u63a5\u7684\u306b\u95a2\u308f\u3063\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u30bf\u30a4\u30d7\u3084\u5909\u7570\u304c\u3001\u8001\u5316\u901f\u5ea6\u3084\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u9577\u5bff\u3068\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u4ee3\u8868\u7684\u306a\u3082\u306e\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u4e88\u9632\u7b56\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u304c\u5065\u5eb7\u9577\u5bff\u306e\u9375\u3068\u306a\u308a\u307e\u3059\u3002 \u5065\u5eb7\u9577\u5bff\u306b\u95a2\u308f\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50 \u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u3067\u3001\u79c1\u305f\u3061\u306f\u81ea\u5206\u81ea\u8eab\u306b\u6700\u9069\u306a\u5065\u5eb7\u7ba1\u7406\u65b9\u6cd5\u3084\u8001\u5316\u4e88\u9632\u306e\u305f\u3081\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3092\u9078\u629e\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002 \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u5065\u5eb7\u9577\u5bff\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1 1. \u6297\u9178\u5316\u5bfe\u7b56\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u7ba1\u7406\uff08FOXO3\u907a\u4f1d\u5b50\uff09 FOXO3\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u304c\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u306b\u8010\u3048\u3001\u5065\u5eb7\u3092\u4fdd\u3064\u3046\u3048\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u5834\u5408\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u5f37\u304f\u306a\u308a\u3001\u7d30\u80de\u306e\u8001\u5316\u901f\u5ea6\u304c\u9045\u304f\u306a\u308a\u307e\u3059\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u306f\u3001\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u304c\u904e\u5270\u306b\u751f\u6210\u3055\u308c\u308b\u72b6\u614b\u3067\u3001\u3053\u308c\u304c\u5897\u3048\u308b\u3068\u7d30\u80de\u304c\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u3001\u8001\u5316\u3084\u75c5\u6c17\u306e\u9032\u884c\u304c\u65e9\u307e\u308b\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002 2. \u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3068\u4ee3\u8b1d\u306e\u6539\u5584\uff08SIRT1\u907a\u4f1d\u5b50\uff09 SIRT1\u907a\u4f1d\u5b50\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3084\u6297\u708e\u75c7\u4f5c\u7528\u3001\u7d30\u80de\u4fee\u5fa9\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u5f79\u5272\u3092\u6301\u3061\u3001\u7279\u306b\u6297\u8001\u5316\u52b9\u679c\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002SIRT1\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u306f\u3001\u7279\u306b\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306b\u3088\u3063\u3066\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304a\u308a\u3001\u8001\u5316\u4e88\u9632\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002 3. \u8a8d\u77e5\u75c7\u4e88\u9632\u3068\u8133\u306e\u5065\u5eb7\uff08APOE\u907a\u4f1d\u5b50\uff09 APOE\u907a\u4f1d\u5b50\u306f\u3001\u4e3b\u306b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002APOE\u907a\u4f1d\u5b50\u306e\u30bf\u30a4\u30d7\uff08\u7279\u306b\u03b54\u578b\uff09\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u305f\u3081\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u8a8d\u77e5\u75c7\u4e88\u9632\u304c\u91cd\u8981\u3067\u3059\u3002 \u65e5\u5e38\u751f\u6d3b\u3067\u53d6\u308a\u5165\u308c\u308b\u3079\u304d\u7fd2\u6163\u3068\u5177\u4f53\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1 \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3066\u3001\u5065\u5eb7\u9577\u5bff\u3092\u76ee\u6307\u3059\u305f\u3081\u306e\u5177\u4f53\u7684\u306a\u751f\u6d3b\u7fd2\u6163\u3092\u4ee5\u4e0b\u306b\u307e\u3068\u3081\u307e\u3059\u3002 1. \u6804\u990a\u30d0\u30e9\u30f3\u30b9\u306e\u898b\u76f4\u3057 \u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u3001\u4e0d\u8db3\u3057\u304c\u3061\u306a\u6804\u990a\u7d20\u3092\u88dc\u3046\u3053\u3068\u306f\u3001\u5065\u5eb7\u9577\u5bff\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\u3092\u4e2d\u5fc3\u306b\u3001\u5fc5\u8981\u306a\u6804\u990a\u3092\u3057\u3063\u304b\u308a\u3068\u6442\u53d6\u3057\u307e\u3057\u3087\u3046\u3002 2. \u9069\u5ea6\u306a\u904b\u52d5\u7fd2\u6163 \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u9069\u5207\u306a\u904b\u52d5\u30d7\u30e9\u30f3\u306f\u3001\u7b4b\u8089\u91cf\u3092\u7dad\u6301\u3057\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u305f\u3081\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u904b\u52d5\u306e\u7a2e\u985e\u3084\u5f37\u5ea6\u3082\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002 3. 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